background: hypertension is considered an independent risk factor for cardiovascular mortality in diabetic patients. the present study was designed to determine the role of gamma amino butyric acid b (gabab) receptor and l-arginine (l-arg) in gaba-induced vasorelaxation in normal and streptozotocin-induced diabetic rat vessels. methods: diabetes was induced by a single i.p. injection of strepto...

Submit Manuscript | http://medcraveonline.com Abbreviations: CAPS-2: Calcium dependent Activator Protein for Secretion 2; BDNF: Brain Derived Neurotrophic Factor; CXCR4: Chemokine Receptor with CXC Motif 4; GABA: Gamma Amino-Butyric Acid; GABA A receptor: Gamma Amino-Butyric Acid Receptor A; GAERS: Genetic Absence Epilepsy Rats from Strasbourg; LGS: Lennox-Gastaut Syndrome; MAP-2: Microtubule A...

1 The effect of inhibiting the transport of gamma-aminobutyric acid (GABA) by neuroglial cells on the depolarizing action of exogenous amino acids on isolated superior cervical ganglia of the rat was studied. 1 Transport (measured by uptake of [3H]-GABA) was inhibited by (a) reducing external [na+] from 143 to 2mM and (b) administering alternative carrier-sbustrates, 3-amino-n-butyric acid (bet...

Gamma-amino butyric acid (GABA) possesses several physiological functions such as neurotransmission, induction of hypotension, diuretic and tranquilizer effects. Production of GABA-enriched products by lactic acid bacteria has been a focus of different researches in recent years because of their safety and health-promoting specifities. In this study, glutamate decarboxylase (gad) gene of a loca...

Valproic acid is widely used as an anti-epileptic globally. Anti-epileptic action is mediated by Gamma Amino Butyric Acid (GABA) receptors. In past and recently, several other clinical outcomes have been proposed by various studies. These under-reported clinical actions apart from anti-epileptic activity are mediated by various intracellular and extracellular pathways. Several mechanisms like H...

Background: There are some reports in the literature showing that hypothalamus synthesizes and secretes amino acid neurotransmitters. According to several studies, elevated serum levels of gamma-amino butyric acid (GABA), a potent inhibitory neurotransmitter, have recently been implicated in the pathogenesis of neural diseases. The purpose of this research was to estimate the effects of curcumi...

gamma-amino butyric acid (gaba) possesses several physiological functions such as neurotransmission, induction of hypotension, diuretic and tranquilizer effects. production of gaba-enriched products by lactic acid bacteria has been a focus of different researches in recent years because of their safety and health-promoting specifities. in this study, glutamate decarboxylase (gad) gene of a loca...

background: there are some reports in the literature showing that hypothalamus synthesizes and secretes amino acid neurotransmitters. according to several studies, elevated serum levels of gamma-amino butyric acid (gaba), a potent inhibitory neurotransmitter, have recently been implicated in the pathogenesis of neural diseases. the purpose of this research was to estimate the effects of curcumi...

Sodium butyrate (NaB) can regulate lipid metabolism and inhibit hepatic steatosis. This study aimed to investigate whether NaB alleviate fructose-induced steatosis via remodeling the gut microbiota evaluate anti-fatty liver mechanisms. The results showed that NaB-remodeled significantly alleviated increased plasma uric acid fructose levels. Furthermore, both abundance of Lactobacillus al...